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HSPH researchers identify key mechanism in cellular growth process

first_img Read Full Story A new study by Harvard School of Public Health (HSPH) researchers is the first to identify the primary mechanism controlling a metabolic process essential for cell growth and proliferation. This pathway is centered around the mTOR protein, which relays growth signals to cells in response to external stimuli, including insulin and nutrients. The scientists speculate that one day researchers may be able to use this new knowledge to develop treatments for certain cancers which have uncontrolled mTOR signaling.The study appeared online in the February 21, 2013 issue of Science Express.Cells closely monitor the availability of growth factors, nutrients, and energy. They respond to growth signals by generating nucleotides, the building blocks of RNA and DNA, which are essential to replicating the cellular genetic material for the new cells. This study is the first to demonstrate a novel control mechanism through which this process occurs, providing a molecular link between growth signals and the synthesis of new nucleotides.The mTOR protein is expressed in all cells in the human body. Its signaling pathway senses and integrates cellular growth signals and acts as a conduit between these signals and the control of specific energy- and nutrient-consuming biosynthetic processes, such as protein and lipid synthesis. This study extends these processes essential to cell growth to include nucleotide synthesis.last_img read more

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NASCAR announces big changes to 2020 Cup Series schedule

first_imgISM Raceway recently underwent a $178 million renovation to enhance the fan experience. NASCAR results at Martinsville: Brad Keselowski dominates field, secures STP 500 win NASCAR is moving a lot of things around in 2020, most significantly, where the championship race will be held.NASCAR announced Tuesday the final race of the year is moving to ISM Raceway in Avondale, AZ. The final race of the year has been held at Homestead Miami Speedway since 2002.This will be a distinct change in racing as Homestead is a 1.5-mile intermediate track while ISM is much shorter at just over a mile. Related Newscenter_img Kyle Busch passes Richard Petty with 201st NASCAR national series win The Arizona race track has hosted a playoff race since 2005 and has been in the rotation since the playoff format changed in 2014.Other changes NASCAR made to the schedule include:Daytona International Speedway will now host the regular-season finalePocono Raceway will host a doubleheaderThe Bristol night race will be the playoff cutoffThe Indianapolis race moves to July 4th weekendMartinsville will now race under the lights on Mother’s Day WeekendDarlington will open the NASCAR playoffs on Sept. 6“The fans and the industry as a whole have been vocal about the desire for sweeping changes to the schedule, and the 2020 slate is a reflection of our efforts to execute against that feedback,” Steve O’Donnell, NASCAR executive vice president and chief racing development officer said. “These changes are the result of unprecedented consensus-building with our race tracks and broadcast partners; something we look to continue into 2021 and beyond.”last_img read more

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